Endocrine Abstracts

Introduction: Local androgen synthesis in prostate cancer (PC) could contribute to the development of castration-resistant PC (CRPC). Pathways controlling intratumoral steroidogenic enzyme expression in PC are unknown. Since activin has been implicated in regulation of PC growth and steroidogenic enzyme expression in other steroidogenic tissues, we investigated the effect of activin on intratumoral steroidogenesis in PC.Methods: Activin A effects and reg...